Nicola Pozzi, PharmD, PhD

Saint Louis University (SLU)

Thrombosis and Hemostasis; Structure and Function of Clotting and Complement Factors; Acquired and Inherited Thrombophilia; Development of Biotherapeutics via Protein Engineering.

Hemostasis is the process which causes bleeding to stop. Inherited genetic and acquired disorders perturbing hemostasis often lead to excess bleeding (hemorrhage) or clotting (thrombosis). For example, hemophilic patients carrying defects in clotting factors VIII (hemophilia A) or IX (hemophilia B) frequently bleed in their muscle and joints. In contrast, patients suffering from FV Leiden, Protein C deficiency, ATIII resistance, VWF disease, Antiphospholipid Syndrome, sepsis and cancer manifest venous and arterial thrombosis leading to pulmonary embolisms, myocardial infarction, stroke, deep vein thrombosis, and organ failure.

In our laboratory, we strive to understand the molecular mechanisms of thrombus formation with the ultimate goal of developing novel biotherapeutics via protein engineering. To do so, we investigate how plasma proteins and clotting factors interplay at the molecular level, how they sense the surrounding microenvironment and how their catalytic machinery works.