Rafael Galindo, MD, PhD
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Washington University in St. Louis (WU)
The focus of my neuroscientific research involves exploring novel neuroprotective strategies and understanding neurobiological mechanisms that regulate neuronal survival and death in the injured neonatal brain. Specifically, I have been examining the role and associated cellular mechanisms of Nicotinamide Mononucleotide Adenylyltransferases (NMNATs), sterile alpha- and armadillo-motif-containing protein (SARM) and human Chorionic Gonadotropin (hCG) receptor in maintaining neuronal survival of injured developing neurons and brain. Understanding the role of these proteins on the survival of injured immature neurons may offer new potential agents and/or cellular targets for the effective treatment and prevention of the immediate and long-term neurological consequences that affect neonates exposed to birth asphyxia. We are also developing new function-based animal models for the systematic evaluation of the neurological comorbidities associated with neonatal cerebral injury. To this end, we are developing new technologies and methods for evaluating cortical network connectivity and seizures during and/or following neonatal ischemia.