Washington University in St. Louis (WU)
My overarching research interest is in gaining insight into mechanisms by which nutrients affect anti-tumor immunity. My current focus involves testing 1) the extent to which endogenous and exogenous polyamines, a family of ubiquitous cations, affect T cell viability, function, development, and differentiation; and 2) the extent to which pharmacologic manipulation of polyamine metabolism can be leveraged to reinvigorate the anti-tumor immune response. In addition, I have a strong interest in identifying the degree to which nutrient consumption affects metabolic regulation of the anti-tumor immune response.