Washington University in St. Louis (WU)
The focus of our laboratory is on developing effective therapies for sepsis. Specifically, we are concentrating on prevention of the widespread apoptosis of immune effector cells that is a hallmark of the disorder. A variety of anti-apoptotic strategies are employed. In addition, we are endeavoring to inhibit the immunosuppressive phenotype that occurs during sepsis and which contributes to the immunoparalysis that is a major feature of this disorder.