Roland E. Dolle, PhD

Director, Center for Drug Discovery

Washington University in St. Louis (WU)

Design and synthesis novel molecular probes and small molecule ligands to aid in the understanding of the mechanistic pathophysiology of human diseases. Identification of drug leads via high-throughput screening and other means. Application of medicinal chemistry and computational chemistry to optimize drug leads for potency, target selectivity, pharmacokinetics, in vivo pharmacology, and safety to yield proprietary clinical drug candidates.