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The theme of Innovation Lab Vanderbilt is Staying Power: Developing Lifestyle Interventions that Last. Ample research is aimed at achieving weight loss and a wide range of intervention types have significant short-term effectiveness, but few have long-term success. One can accept that this frustrating reality represents a struggle against human nature to return to ingrained patterns, or propose that we are simply not adequately focused on the next step, which is supporting change, preventing relapse and exploiting novel tools to do so.