Author: Cifarelli, Vincenza PhD

15. PET Imaging Cardiac Inflammation in CD36-deficient Individuals

Introduction: Fatty acid translocase CD36 regulates cardiac function, and its deletion in rodents associates with atrioventricular block and bradycardia and increasing risk of sudden death following prolonged fasting. Preclinical and clinical research show that monocyte chemotactic protein-1/chemokine (C-C motif) receptor 2 (MCP-1/CCR2) regulates myocardial remodeling and inflammation during cardiac disease. Our preliminary data, conducted with […]

2. PET Imaging Cardiac Inflammation in CD36-deficient Individuals

Introduction: Our study will assess myocardial inflammation in individuals with dysfunctional lipid metabolism using a novel non-invasive positron emission tomography (PET) imaging approach. Fatty acid (FA) translocase CD36 regulates myocardial FA uptake, remodeling and inflammation. CD36 deletion in rodents associates with atrioventricular block and bradycardia; and risk of sudden death following prolonged fasting. In humans, […]