1. Characterizing the Genetic Factors Driving Rheumatoid Arthritis Inflammatory Interactions Using an SF-Chondrocyte Co-Culture Model

Introduction: Rheumatoid arthritis (RA) is an autoimmune joint-debilitating disease caused by genetic and environmental factors and affects more than 1 million Americans today. Studies have characterized several mechanisms for RA onset, identifying cytokines like IL-1, IL-2, and IL-6, as well as different receptors, as important in guiding the degrading cellular interactions in the articular microenvironment. […]

2. PET Imaging Cardiac Inflammation in CD36-deficient Individuals

Introduction: Our study will assess myocardial inflammation in individuals with dysfunctional lipid metabolism using a novel non-invasive positron emission tomography (PET) imaging approach. Fatty acid (FA) translocase CD36 regulates myocardial FA uptake, remodeling and inflammation. CD36 deletion in rodents associates with atrioventricular block and bradycardia; and risk of sudden death following prolonged fasting. In humans, […]

3. Assessment of CCR2 PET for Abdominal Aortic Aneurysm Rupture Prediction and Determination of Treatment Response

Introduction: Abdominal aortic aneurysms (AAA) are a life-threatening degenerative vascular disease without any effective medical therapy or imaging approach to predict the risk of rupture. AAAs occur later in life and are especially prevalent in men over the age of 65, but are more likely to rupture in women. Previously, we evaluated the efficiency of […]

4. Immunologic Response to Ivermectin Treatment of Loiasis

Introduction: Loiasis related post-ivermectin (IVM) adverse events (AEs) hinder lymphatic filariasis (LF)/onchocerciasis elimination in co-endemic areas. Findings from LF suggest that post-IVM AEs might be the result of immune responses to filarial or Wolbachia antigens released by dying microfilariae (Mf). The aim of this study was to determine whether IVM treatment of loiasis, devoid of […]

5. Integrative Analysis of DNA Methylation and RNA-seq Data for Biomarker Detection of Endometriosis

Introduction: Endometriosis, a complex and common gynecological disorder affecting 5-10% of reproductive-age women, is characterized by the growth of endometrial tissues outside of the uterine cavity. About 176 million women worldwide suffer from endometriosis. The current diagnostic process is laparoscopy, which is a risk-associated and costly invasive procedure. On average it takes 10 years to […]

6. Antithrombogenic Sutureless Vaso-Lock for Vascular Anastomosis

Introduction: Micro- and macrovascular anastomoses involve suturing together of blood vessels, which is a critical foundational surgical skill. However, it is costly, time-consuming, and prone to complications. Our team has created a unique anastomotic device, Vaso-Lock, as a sutureless coupler. Vaso-Lock is intraluminal, holding free vascular ends together with traction by anchors. In terms of […]

7. Developing Antisense Oligonucleotides Targeting MiR-29b Binding Site to Increase Progranulin Protein Levels for Frontotemporal Dementia

Introduction: Frontotemporal dementia (FTD) is a devastating neurological disease with no approved treatment or cure. One common cause of FTD is heterozygous loss-of-function GRN mutations, which result in progranulin haploinsufficiency. Antisense oligonucleotides (ASOs) are emerging as a promising therapeutic modality for neurological diseases, but ASO-based strategies for increasing target protein levels are limited. Several microRNAs […]

8. Development of an HPLC-based Method for the Separation of Transferrin Forms in Murine Serum

Introduction: Transferrin (Tf) is the primary iron binding protein in serum. It has two homologous lobes, N and C, that can each bind one iron molecule. Thus, Tf exists in four forms, apo-, monoferric N, monoferric C and holo-Tf. At physiologic Tf saturations, the monoferric Tfs are the predominant forms. Using mice genetically engineered to […]

9. Combined Inhibition of Myostatin and Activin A Enhances Femoral Microarchitecture and Strength in a Type I/IV Osteogenesis Imperfecta Mouse Model

Introduction: Current therapeutics for osteogenesis imperfecta (OI), a heritable connective tissue disorder characterized by skeletal fragility and impaired bone cell function, are limited to bisphosphonates. Soluble activin receptor type IIB (sActRIIB) decoy molecules, which bind transforming growth factor-β (TGF-β) ligands, including myostatin and activin A, have increased skeletal bone properties in murine models of OI, […]

10. Microgel Fabrication for Sustained Delivery of PRP to Treat Osteoarthritis

Introduction: Osteoarthritis (OA) is a debilitating joint disease that affects 50+ million American adults. Current treatment options are not optimal. Platelet-rich plasma (PRP) is a promising option. However, when PRP is delivered intra-articularly, it is rapidly cleared from the joint, diminishing treatment efficacy. We hypothesize that a delivery vehicle that can sustain PRP release will […]