Category: Clinical

Introduction: Inhibiting epigenetic modulators can transcriptionally reactivate transposable elements (TEs). These TE transcripts often generate unique peptides that can serve as novel antigens for immunotherapy. Here, we asked if TEs activated by epigenetic therapy could appreciably increase the antigen repertoire in glioblastoma, an aggressive brain cancer with low mutation and neoantigen burden. Methods: We treated […]

Introduction: While internal anal sphincter (IAS) Botox has been increasingly utilized in children with disordered defecation (DD), no literature regarding clinical efficacy or quality of life (QoL) influence exists. Therefore, we aimed to elucidate the effect of IAS Botox as an adjunct to standard treatment for DD on patient/caregiver QoL metrics in association with corresponding […]

Introduction: Pregnant individuals with substance use disorders (SUD) are at higher risk of developing severe complications from COVID-19. Infants < 6 months are also at significant risk. Vaccination in perinatal individuals can help protect both mother and infant from severe outcomes; however, vaccine hesitancy is high. We evaluated COVID-19 vaccination rates among postpartum patients with […]

Introduction: Multiple sclerosis (MS) causes central nervous system lesions that alter neural communication between the brain and the spinal motoneurons that activate muscles. These voluntary motor commands consist of three components that must be appropriately balanced for skilled motor control: excitation, inhibition, and neuromodulation. Disruption of this balance has harmful effects, evidenced by work in […]

Introduction: Assessment of comorbid cardiovascular disease can predict health outcomes and may risk-stratify patients for adverse events and death. Current methods used to estimate patient risk, such as the Charlson Comorbidity Index (CCI), are based on International Classification of Diseases (ICD) codes, which are a poor indicator of severity and complexity of comorbid disease. In […]

Introduction: Burnout in medical trainees significantly increases their risk of suicidal ideation, and trainees are often reluctant to seek mental health care. Digital mindfulness and cognitive behavioral therapy (CBT) principles are evidence-based preventative strategies for reducing burnout and increasing professional satisfaction. We are conducting a randomized pilot study to assess whether digital interventions for CBT-based […]