Category: Early Stage

Introduction: Tendon injuries are among the most common and challenging orthopedic conditions. Many patients suffer from long-term pain and reduced function primarily due to an imbalanced healing response with excessive inflammation and inadequate regeneration. We found that extracellular vesicles produced by inflammation-primed adipose stem cells (iEV) can attenuate inflammation. It remains to be determined if […]

Introduction: Cerebral palsy (CP) is the most common physical disability in childhood characterized by irreversible, non-progressive central motor dysfunction. Genetic factors, and environmental insults such as prematurity and hypoxia-ischemia, can contribute to CP.  However, significant gaps in our knowledge of the genetic basis of CP impede advances in preventive, diagnostic, and therapeutic measures. We recently […]

Introduction: DNA sequencing assays have been used to characterize the vaginal microbiome and identify associations with reproductive outcomes. These assays are useful but can be prohibitively expensive and time consuming. The purpose of this study was to demonstrate the utility of the NanoString nCounter platform, a more efficient assay compared to sequencing, for characterization of […]

Introduction: Next-generation sequencing (NGS) allows the comprehensive characterization of the virome and discovery of novel viruses, as it enables culture-independent, agnostic assessment of viral nucleic acid within a sample. We have produced software in the form of an automated pipeline, ViroMatch, that takes raw NGS sequencing reads as input and performs read quantification and associated […]

Introduction: Focused ultrasound (FUS)-enabled liquid biopsy (sonobiopsy) is an emerging technique for the noninvasive and spatial-temporally controlled diagnosis of brain cancer by inducing blood-brain barrier (BBB) disruption to release brain tumor-specific biomarkers into the blood circulation. The feasibility, safety, and efficacy of sonobiopsy were demonstrated in both small and large animal models using magnetic resonance-guided […]