The Washington University Institute of Clinical and Translational Sciences (ICTS) hosted their 5th annual Symposium and Poster Display on Thursday, May 18, 2023. This year’s theme, “Advancing Clinical/Translational Science at an Academic Healthcare System” focused on how academic institutions, hospitals, and communities can partner in clinical and translational research to improve patient outcomes and, ultimately, […]
The ICTS has awarded five awards to investigators in the ICTS’ 2nd annual virtual poster display and contest. As part of the 5th annual ICTS Symposium, 38 posters were submitted and reviewed by 17 ICTS faculty from Washington University in St. Louis, University of Missouri – Columbia, and Saint Louis University. Posters showcased translational research […]
Researchers ID shortcomings in stem cell-derived beta cells, paving way to improved diabetes treatments Diabetes researchers at Washington University School of Medicine in St. Louis have uncovered at least one reason insulin-secreting cells made from stem cells in the lab don’t work as well as natural cells. The discovery could help speed progress toward making […]
Researchers at Washington University School of Medicine in St. Louis have identified four important signs and symptoms that signal an elevated risk of early-onset colorectal cancer. These red flags may be key to earlier detection and diagnosis of early-onset colorectal cancer among younger adults. The number of young adults with colorectal cancer has nearly doubled […]
Fumihiko Urano, MD, PhD is featured in the Rocky Mountain PBS documentary “Colorado Voices: Ellie White” for his ICTS-supported research on Wolfram Syndrome.
Pamela K. Woodard, MD, a national leader in cardiothoracic imaging, has been named head of the Department of Radiology, director of Mallinckrodt Institute of Radiology (MIR) and the Elizabeth E. Mallinckrodt Professor of Radiology at Washington University School of Medicine in St. Louis. She will begin her new role July 1.
Introduction: Mutations in mitochondrial genes underlie numerous neurodegenerative diseases, yet the significance of most variants is uncertain concerning disease phenotypes. Many pathogenic mutations cause visibly distinct morphological differences in afflicted cells, allowing human cells to serve as proxies for patients when studying the genetic basis of disease. This postulate provides the basis for a pooled […]
Introduction: Most dementia patients have co-existing vascular contributions to cognitive impairment and dementia (VCID). Cerebral amyloid angiopathy (CAA), a form of vascular dementia, bridges the interplay between VCID and Alzheimer’s Disease (AD) pathology and cooccurs in 90% of patients with AD. The hallmark pathology of CAA is characterized by amyloid-ß deposition in cerebrovasculature. Reactive oxidative […]
Introduction: Germinal matrix hemorrhage-intraventricular hemorrhage (GMH-IVH) is a pathologic condition which preferentially effects premature neonates, some of which later develop posthemorrhagic hydrocephalus (PHH). To date, no study has attempted to provide a head-to-head comparison of structural alterations which occur based on age of hemorrhagic insult. This study aims to provide a time course of age-dependent […]
Introduction: Micro- and macrovascular anastomoses involve suturing together of blood vessels, which is a critical foundational surgical skill. However, it faces many challenges, such as decade-long training and inherent dexterity of the surgeon. Procedures are long and expensive, require specialized operating rooms and equipment, making them prohibitive in many hospitals. Our team has created a […]