Introduction: Acute hypoxemic respiratory failure (RF) is the hallmark symptom of COVID-19 infection that can lead to escalating oxygenation requirements and critical care utilization. Early identification of patients at risk for respiratory decompensation can facilitate timely resource deployment and mitigate care delays. To facilitate resource alignment with patient needs, a machine learning (ML) model designed […]

Introduction: Fatigue significantly impacts daily functioning for people with disabilities (PwD). Self-management programs targeting fatigue have shown promising effects for PwD. However, current satisfaction with fatigue self-management programs is low for PwD. Tailoring a self-management intervention based on patient activation may overcome this issue. This study aimed to describe the development of a mobile phone-based […]

Introduction: Hand dermatitis is a common dermatologic condition with a lifetime prevalence estimated to be 20%. The objective of this study was to assess the demographics and patch test positivity in adult patients who underwent patch testing at our institution with a focus on patients with hand dermatitis. We hypothesize that tobacco smoking is a […]

Introduction: Healthcare-associated infections acutely threaten intensive care units (ICUs) with studies indicating that Pseudomonas aeruginosa (PSAR) reservoirs in hospital built-environments can lead to infections and outbreaks. Despite this, it is unclear how pervasively antibiotic resistant organisms (AROs) like PSAR colonize ICU surfaces. We sampled surfaces in a newly-built stem cell transplant and oncology ICU before […]

Introduction: The late onset and unusual microbiology of some breast-implant associated infections suggests local skin microbiota as a possible source of infecting bacteria. Methods: Breast and axillary skin swabs, antibiotics, and skin product use were collected from women planning to undergo mastectomy with immediate implant reconstruction during the preoperative and up to four postoperative clinic […]

Introduction: There is a severe shortage of available liver transplants to meet the needs of patients on the waiting list. There are many factors contributing to this shortage and poor organ utilization is a significant one. A large proportion (~20-35%) of livers are discarded based on subjective assessment and concern for organ quality. Objective criteria […]

Introduction: Belimumab (BEL) is a monoclonal antibody which inhibits binding of B-cell-activating factor (BAFF) to its receptors on B cells, thus inhibiting the survival of alloreactive B cells. Given the role of B cells and BAFF in chronic Graft-versus-Host Disease (cGvHD) pathophysiology, BEL might have a role in prevention of cGvHD. We hypothesized that targeting […]

Introduction: Genetic variation in nicotinic receptor subunits explains differences in smoking behaviors and risk of smoking-related diseases. Still, it remains unknown whether returning genetic susceptibility results can motivate smoking cessation and personalize treatment. Therefore, the aim of this trial is to investigate the effects of a genetically informed smoking cessation intervention on a) smoking quantity […]

Introduction: Preclinical evidence suggests that responses to IO may be enhanced through the immunomodulatory effects of stereotactic radiation therapy (SRT). We hypothesized that clinical outcomes from the National Cancer Database (NCDB) would demonstrate improved overall survival (OS) in mRCC patients receiving IO+SRT versus IO alone.  Methods: Patients with mRCC diagnosed from 2012-2016 and receiving first-line […]

Introduction: Cellular stressors play an important role in the emergence of clonal hematopoiesis (CH). Cytotoxic chemotherapy is associated with CH due to mutations in DNA damage response (DDR) genes, such as TP53, ATM, and PPMID. Lung transplant (LTx) recipients receive lifelong immunosuppression therapy and are known to be at increased risk for a broad spectrum […]