34. In-utero Exposure to a Devastating Hurricane is Associated with Altered Infant Nasal Microbiome

By •

Introduction: Prenatal maternal exposures to environmental or psychological stressors increase the risks for developing respiratory diseases, including wheezing and asthma, in children. With the increasing frequency and intensity of extreme weather events worldwide, which poses dramatic environmental and psychological burdens in affected regions, it is essential to evaluate the risks of developing respiratory diseases among […]

35. Dietary Protein Elicits a Leucine-mediated Threshold Effect on Monocyte/Macrophage mTORC1-autophagy Signaling Resulting in Elevated Cardiovascular Risk

By •

Introduction: High-protein intake is common in Western societies and generally considered healthy. However, results from studies on both participants and mice suggest elevated protein intake is associated with increased risk for cardiovascular diseases, although the dose at which protein intake can trigger mTOR activation and reach unhealthy levels and the specific amino acid(s) responsible for […]

36. Myocardial Oxygen Extraction Fraction Imaging with MRI

By •

Introduction: Imbalance of myocardial oxygen supply and demand precipitates a cascade of physiological changes resulting in ischemic pathology. Myocardial oxygen extraction fraction (mOEF) may provide accurate assessment of this balance. Current non-invasive reference method to quantify mOEF is positron emission tomography (PET), but the low spatial resolution, high cost, and ionizing radiation discourage the widespread […]

37. Translating for Impact: A New Toolkit for Demonstrating the Larger Impact of Your Work

By •

Introduction: Historically, researchers have focused on linking research to scientific outputs like publications and grants. But policymakers, the public, and funders care about the larger impact of research (e.g., lives saved, improved cost-effectiveness). Developed in 2017, the Translational Science Benefits Model offers a new approach for evaluating and disseminating the impact of scientific activities on […]

38. The Impact on Families of Congenital Upper Extremity Differences

By •

Introduction: Congenital upper extremity differences often carry inherent functional limitations, aesthetic concerns, and the need for surgical treatment. We hypothesize that 1) caregivers of children with these differences will report a significant impact on family life, and 2) this impact would vary based on certain variables, such as insurance status. Methods: Caregivers of patients age […]

39. We’re All Running on Empty: ICTS Membership Engagement and Productivity in the COVID Era

By •

Introduction: COVID-19 swept through the United States beginning in March 2020, leading to transitions from in-person to online collaboration and teaching, overhauled lab safety protocols and schedules, and overwhelming clinical responsibilities for physicians. This study examines changes in ICTS members’ engagement with ICTS activities and productivity. Specific aims are to 1) document changes in activity […]

40. If You Build It, Will They Come? Linking ICTS Researcher Engagement and Scientific Productivity

By •

Introduction: The NIH Clinical and Translational Science Awards (CTSA) Program supports the creation of program infrastructure promoting scientific collaboration and improvement in translational research. While most evaluations of these and similar programs focus on scientific outcomes such as grants and publications, few studies investigate the underlying mechanisms through which large infrastructure grants produce scientific or […]

41. Parent and Provider Perspectives on a Developmental Screening and Therapy Referral Program for Children 0-3 years with Sickle Cell Disease

By •

Introduction: Sickle cell disease (SCD) is an inherited blood disorder affecting approximately 100,000 people in the United States. Children with SCD experience severe pain and stroke. A lesser-known side effect can be developmental deficits. Early intervention (EI) can help reduce the impact of deficits. Screening for deficits in the first years of life can support […]

42. Collecting Early Childhood Obesity Measurements Through a Home Visiting Program: A Proof-of-Concept Study

By •

Introduction: Community-based home visiting programs are recommended vehicles for early life-course interventions to prevent childhood obesity. We developed and implemented a proof-of-concept protocol for collecting child weight and length or height data for children aged 6 months to 5 years through Parents as Teachers (PAT) affiliates that were geographically dispersed throughout the United States. Methods: […]

43. The Indigenous Health Toolkit: Results of a Pilot Test from Two Sites

By •

Introduction: Compared to all other racial/ethnic groups in the United States (US), Indigenous People (IP) suffer from the largest mental health, substance use, and physical health disparities. Ethnicity and race play a role in the quality of care and treatment patients receive within the medical system. Specifically, discrimination and bias are associated with health disparities […]