Introduction: Next-generation sequencing (NGS) allows the comprehensive characterization of the virome and discovery of novel viruses, as it enables culture-independent, agnostic assessment of viral nucleic acid within a sample. We have produced software in the form of an automated pipeline, ViroMatch, that takes raw NGS sequencing reads as input and performs read quantification and associated […]
Introduction: Focused ultrasound (FUS)-enabled liquid biopsy (sonobiopsy) is an emerging technique for the noninvasive and spatial-temporally controlled diagnosis of brain cancer by inducing blood-brain barrier (BBB) disruption to release brain tumor-specific biomarkers into the blood circulation. The feasibility, safety, and efficacy of sonobiopsy were demonstrated in both small and large animal models using magnetic resonance-guided […]
Introduction: Neurological side effects after chimeric antigen receptor-modified (CAR) T cell therapy, termed immune effector cell-associated neurotoxicity syndrome (ICANS), are common and potentially devastating. We previously demonstrated that pre-infusion plasma neurofilament light chain (NfL), a well-established marker neurodegeneration, may predict subsequent development of ICANS in a small, single-center cohort. This larger, multicenter study compares pre-infusion […]
Introduction: A typical regimen for transgender females includes estrogen to provide feminizing effects in conjunction antiandrogens. There is no data to indicate if a single daily dose vs divided daily doses vs continuous subcutaneous dosing of estradiol is more effective at suppressing endogenous testosterone production. The lack of research on gender affirming hormone therapy represents […]
Introduction: The composition of real world dental aerosols remained poorly understood. Previous studies have used in vitro experimental designs and/or indirect measures to evaluate bacteria and viruses from dental splatter. However, these findings may overestimate the occupational health risks for dental healthcare personnel (DHCP). The purpose if this study is to directly measure dental aerosol […]
Introduction: Urgency and frequency are common lower urinary tract symptoms (UFLUTS) in women. There is limited evidence to guide physical therapist-led treatment. The focus of this project was to understand how pelvic floor muscle (PFM) strength and endurance, PFM mobility, and hip muscle strength differ between women with and without UFLUTS. Methods: Women with (n=21) […]
Introduction: The STOP COVID Trials were innovative, fully-remote randomized controlled trials of fluvoxamine (a sigma1 receptor agonist with anti-inflammatory properties) vs placebo for treatment of outpatients with early COVID-19 who were self-isolating at home. Methods: The trials used eConsent and an electronic data capture system with integrated recruitment from the Epic electronic health record system. […]
Introduction: Although depression and anxiety negatively impact patients’ responses to standard orthopedic treatment, mental health is not routinely addressed in orthopedic care. Digital mental health interventions may be a feasible, effective way to address mental health in orthopedic care settings, but recent literature calls for more comparison data between digital interventions and other treatment arms. […]
Introduction: Airborne transmission of SARS-CoV-2 is thought to be greatest during aerosol-generating procedures (AGP) in the hospital. The true risk posed by AGPs is not well understood. Methods: Aerosol capture and real-time particle size characterization were performed in the medical intensive care unit (MICU) during mechanical ventilation, bi-level positive airway pressure (BiPAP) ventilation, high-flow nasal […]
Introduction: Emergency department (ED) healthcare personnel (HCP) provide acute medical care to the ill and injured. The day-to-day burden of aerosol exposure posed to ED HCP during patient care is not well understood, but remains a concern during the COVID-19 pandemic. Methods: Baseline air quality and aerosol characterization during routine ED patient care and emergent […]