Category: 2022 ICTS Symposium Posters

11. Extracellular Vesicles from Inflammation-primed Adipose Stem Cells Improve Tendon Healing Through Restoring Balanced Response Following Tendon Injury and Repair

Introduction: Tendon injuries are among the most common and challenging orthopedic conditions. Many patients suffer from long-term pain and reduced function primarily due to an imbalanced healing response with excessive inflammation and inadequate regeneration. We found that extracellular vesicles produced by inflammation-primed adipose stem cells (iEV) can attenuate inflammation. It remains to be determined if […]

12. A Genome-wide Assessment of Non-coding Risk Variants in Cerebral Palsy

Introduction: Cerebral palsy (CP) is the most common physical disability in childhood characterized by irreversible, non-progressive central motor dysfunction. Genetic factors, and environmental insults such as prematurity and hypoxia-ischemia, can contribute to CP.  However, significant gaps in our knowledge of the genetic basis of CP impede advances in preventive, diagnostic, and therapeutic measures. We recently […]

13. Comparison of Metagenomic Sequencing and the NanoString nCounter Analysis System for Characterization of Bacterial and Viral Communities in Vaginal Samples

Introduction: DNA sequencing assays have been used to characterize the vaginal microbiome and identify associations with reproductive outcomes. These assays are useful but can be prohibitively expensive and time consuming. The purpose of this study was to demonstrate the utility of the NanoString nCounter platform, a more efficient assay compared to sequencing, for characterization of […]

14. ViroMatch: A Computational Pipeline for Detection of Viral Reads from Complex Metagenomic Data

Introduction: Next-generation sequencing (NGS) allows the comprehensive characterization of the virome and discovery of novel viruses, as it enables culture-independent, agnostic assessment of viral nucleic acid within a sample. We have produced software in the form of an automated pipeline, ViroMatch, that takes raw NGS sequencing reads as input and performs read quantification and associated […]

15. Development of a Neuronavigation-guided Sonobiopsy Device for Glioblastoma Patients

Introduction: Focused ultrasound (FUS)-enabled liquid biopsy (sonobiopsy) is an emerging technique for the noninvasive and spatial-temporally controlled diagnosis of brain cancer by inducing blood-brain barrier (BBB) disruption to release brain tumor-specific biomarkers into the blood circulation. The feasibility, safety, and efficacy of sonobiopsy were demonstrated in both small and large animal models using magnetic resonance-guided […]

16. Pre-infusion Neurofilament Light Chain (NfL) Levels Predict Immune Effector Cell-associated Neurotoxicity Syndrome (ICANS)

Introduction: Neurological side effects after chimeric antigen receptor-modified (CAR) T cell therapy, termed immune effector cell-associated neurotoxicity syndrome (ICANS), are common and potentially devastating. We previously demonstrated that pre-infusion plasma neurofilament light chain (NfL), a well-established marker neurodegeneration, may predict subsequent development of ICANS in a small, single-center cohort. This larger, multicenter study compares pre-infusion […]

17. Effectiveness, Safety, and Tolerability of Different Estradiol Replacement Therapy Presentations in Transgender Females

Introduction: A typical regimen for transgender females includes estrogen to provide feminizing effects in conjunction antiandrogens. There is no data to indicate if a single daily dose vs divided daily doses vs continuous subcutaneous dosing of estradiol is more effective at suppressing endogenous testosterone production. The lack of research on gender affirming hormone therapy represents […]

18. Biological and Chemical Characterization of Aerosols Emitted During Dental Procedures in Real World Settings

Introduction: The composition of real world dental aerosols remained poorly understood. Previous studies have used in vitro experimental designs and/or indirect measures to evaluate bacteria and viruses from dental splatter. However, these findings may overestimate the occupational health risks for dental healthcare personnel (DHCP). The purpose if this study is to directly measure dental aerosol […]

19. Musculoskeletal Impairments Among Women with Urinary Urgency/Frequency

Introduction: Urgency and frequency are common lower urinary tract symptoms (UFLUTS) in women. There is limited evidence to guide physical therapist-led treatment. The focus of this project was to understand how pelvic floor muscle (PFM) strength and endurance, PFM mobility, and hip muscle strength differ between women with and without UFLUTS. Methods: Women with (n=21) […]

20. Coming Up with a COVID (Cure?): Using eConsent and National Recruitment in a Fully-Remote Clinical Trial

Introduction: The STOP COVID Trials were innovative, fully-remote randomized controlled trials of fluvoxamine (a sigma1 receptor agonist with anti-inflammatory properties) vs placebo for treatment of outpatients with early COVID-19 who were self-isolating at home. Methods: The trials used eConsent and an electronic data capture system with integrated recruitment from the Epic electronic health record system. […]