Category: 2022 ICTS Symposium Posters

31. Emerging Evidence of Behavior Change Associated with Fully Remote Delivery of a Genetically Informed Smoking Cessation Intervention

Introduction: Genetic variation in nicotinic receptor subunits explains differences in smoking behaviors and risk of smoking-related diseases. Still, it remains unknown whether returning genetic susceptibility results can motivate smoking cessation and personalize treatment. Therefore, the aim of this trial is to investigate the effects of a genetically informed smoking cessation intervention on a) smoking quantity […]

32. Survival in Metastatic Renal Cell Carcinoma Treated with Immunotherapy and Stereotactic Radiation Therapy or Immunotherapy Alone

Introduction: Preclinical evidence suggests that responses to IO may be enhanced through the immunomodulatory effects of stereotactic radiation therapy (SRT). We hypothesized that clinical outcomes from the National Cancer Database (NCDB) would demonstrate improved overall survival (OS) in mRCC patients receiving IO+SRT versus IO alone.  Methods: Patients with mRCC diagnosed from 2012-2016 and receiving first-line […]

33. Clonal Hematopoiesis in Lung Transplant Recipients is Associated with Adverse Clinical Outcomes

Introduction: Cellular stressors play an important role in the emergence of clonal hematopoiesis (CH). Cytotoxic chemotherapy is associated with CH due to mutations in DNA damage response (DDR) genes, such as TP53, ATM, and PPMID. Lung transplant (LTx) recipients receive lifelong immunosuppression therapy and are known to be at increased risk for a broad spectrum […]

34. In-utero Exposure to a Devastating Hurricane is Associated with Altered Infant Nasal Microbiome

Introduction: Prenatal maternal exposures to environmental or psychological stressors increase the risks for developing respiratory diseases, including wheezing and asthma, in children. With the increasing frequency and intensity of extreme weather events worldwide, which poses dramatic environmental and psychological burdens in affected regions, it is essential to evaluate the risks of developing respiratory diseases among […]

35. Dietary Protein Elicits a Leucine-mediated Threshold Effect on Monocyte/Macrophage mTORC1-autophagy Signaling Resulting in Elevated Cardiovascular Risk

Introduction: High-protein intake is common in Western societies and generally considered healthy. However, results from studies on both participants and mice suggest elevated protein intake is associated with increased risk for cardiovascular diseases, although the dose at which protein intake can trigger mTOR activation and reach unhealthy levels and the specific amino acid(s) responsible for […]

36. Myocardial Oxygen Extraction Fraction Imaging with MRI

Introduction: Imbalance of myocardial oxygen supply and demand precipitates a cascade of physiological changes resulting in ischemic pathology. Myocardial oxygen extraction fraction (mOEF) may provide accurate assessment of this balance. Current non-invasive reference method to quantify mOEF is positron emission tomography (PET), but the low spatial resolution, high cost, and ionizing radiation discourage the widespread […]

37. Translating for Impact: A New Toolkit for Demonstrating the Larger Impact of Your Work

Introduction: Historically, researchers have focused on linking research to scientific outputs like publications and grants. But policymakers, the public, and funders care about the larger impact of research (e.g., lives saved, improved cost-effectiveness). Developed in 2017, the Translational Science Benefits Model offers a new approach for evaluating and disseminating the impact of scientific activities on […]

38. The Impact on Families of Congenital Upper Extremity Differences

Introduction: Congenital upper extremity differences often carry inherent functional limitations, aesthetic concerns, and the need for surgical treatment. We hypothesize that 1) caregivers of children with these differences will report a significant impact on family life, and 2) this impact would vary based on certain variables, such as insurance status. Methods: Caregivers of patients age […]

39. We’re All Running on Empty: ICTS Membership Engagement and Productivity in the COVID Era

Introduction: COVID-19 swept through the United States beginning in March 2020, leading to transitions from in-person to online collaboration and teaching, overhauled lab safety protocols and schedules, and overwhelming clinical responsibilities for physicians. This study examines changes in ICTS members’ engagement with ICTS activities and productivity. Specific aims are to 1) document changes in activity […]

40. If You Build It, Will They Come? Linking ICTS Researcher Engagement and Scientific Productivity

Introduction: The NIH Clinical and Translational Science Awards (CTSA) Program supports the creation of program infrastructure promoting scientific collaboration and improvement in translational research. While most evaluations of these and similar programs focus on scientific outcomes such as grants and publications, few studies investigate the underlying mechanisms through which large infrastructure grants produce scientific or […]